|Promotion||Total Nonstop Action Wrestling|
|Date||May 14, 2006|
|Venue||TNA Impact! Zone|
Sacrifice (2006) was a professional wrestling pay-per-view (PPV) event produced by Total Nonstop Action Wrestling (TNA), which took place on May 14, 2006 at the TNA Impact! Zone in Orlando, Florida. It was the second event under the Sacrifice chronology. Eight professional wrestling matches were featured on the event's cards.